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studies the control of metabolic homeostasis by kinase networks centred on the mammalian target of rapamycin (m TOR).
We adopt cell biology, biochemistry, proteomics, and systems approaches.
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Hence, we aim to identify novel m TOR network components and delineate their interconnection in relation to different metabolic inputs and outputs.
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m TOR is a central controller of metabolism and ageing.
m TOR is dysregulated in most cancers as well as in metabolic and neurodegenerative and congenital disorders, and is therefore of major biomedical interest as a drug target and biomarker.